Lupus Coagulation Inhibitor

An antiphospholipid antibody found in association with a variety of diseases (e.g., SYSTEMIC LUPUS ERYTHEMATOSUS and ANTIPHOSPHOLIPID SYNDROME) as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

Also Known As:

Lupus Anticoagulant; Anticoagulant, Lupus; Coagulation Inhibitor, Lupus; Inhibitor, Lupus Coagulation; Anticoagulant Autoantibody, Lupus; Autoantibody, Lupus Anticoagulant; Lupus Anticoagulant Autoantibodies; Lupus Anticoagulant Autoantibody

Pharmalogical Action Categories:

Immunologic Factors

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        Antiphospholipid Antibodies: 4891
        Lupus Coagulation Inhibitor: 2215
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        Antiphospholipid Antibodies: 4891
        Lupus Coagulation Inhibitor: 2215
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        Antiphospholipid Antibodies: 4891
        Lupus Coagulation Inhibitor: 2215
Biological Factors: 2472
- Blood Coagulation Factor Inhibitors: 1
  - Lupus Coagulation Inhibitor: 2215

J A Boscia Selected Research

J A Boscia Research Topics

Disease

Drug/Important Bio-Agent (IBA)